Cable-stayed bridge has been widely used in the construction of high-speed railways because of its strong leapfrogging ability and its ability to effectively avoid adverse terrain. However, due to its difficult construction, numerous technological processes and complex construction organization, environmental factors and other issues have become the focus of the engineering community. In this paper, the construction characteristics of the composite girder cable-stayed bridge are analyzed based on the research background of the Jiya Waterway Super Large Bridge, the key and difficult problems in construction, such as construction period control, double-wall steel cofferdam for bearing platform of main pier in water, main tower of cable-stayed bridge, steel-concrete main beam and steel-concrete combination section, are analyzed, combined with the existing construction technology, this paper studies the key and difficult countermeasures for the construction of the cable-stayed bridge, and puts forward the corresponding solutions, which provide reference for the safe construction of the same type of cable-stayed bridge..