The engineering interface of large railway hub passenger station has the characteristics of many types, strong professionalism, complexity and great coordination difficulty. The interface management adhere to the principles of systematic management, key interface control, management intensity reduction and hierarchical management. According to the modern engineering interface theory, the interface management measures and methods as the standard section (contract) interface method, the integrated management method, the dynamic and static conversion method, the work breakdown structure method and the meeting are proposed, the application tools such as the interface clarification table and the interface list are selected according to the project scale and complexity and the comprehensive ability of the manager, so as to the harmonious goal of the interface.